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Dietary restriction involves NAD(+)-dependent mechanisms and a shift toward oxidative metabolism
Interventions that slow aging and prevent chronic disease may come from an understanding of how dietary restriction (DR) increases lifespan. Mechanisms proposed to mediate DR longevity include reduced mTOR signaling, activation of the NAD(+)-dependent deacylases known as sirtuins, and increases in N...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BlackWell Publishing Ltd
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244309/ https://www.ncbi.nlm.nih.gov/pubmed/25257342 http://dx.doi.org/10.1111/acel.12273 |