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Hydrogen–deuterium exchange in imidazole as a tool for studying histidine phosphorylation
Isotope exchange at the histidine C(2) atom of imidazole in D(2)O solution is well known to occur at a significantly slower rate than the exchange of amide protons. Analysis of the kinetics of this isotope-exchange reaction is proposed herein as a method of detecting histidine phosphorylation. This...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244536/ https://www.ncbi.nlm.nih.gov/pubmed/25354888 http://dx.doi.org/10.1007/s00216-014-8218-5 |