DNA methylation regulates expression of VEGF-C, and S-adenosylmethionine is effective for VEGF-C methylation and for inhibiting cancer growth

DNA hypomethylation may activate oncogene transcription, thus promoting carcinogenesis and tumor development. S-adenosylmethionine (SAM) is a methyl donor in numerous methylation reactions and acts as an inhibitor of intracellular demethylase activity, which results in hypermethylation of DNA. The m...

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Detalles Bibliográficos
Autores principales: Da, M.X., Zhang, Y.B., Yao, J.B., Duan, Y.X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2014
Materias:
Biomedical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244666/
https://www.ncbi.nlm.nih.gov/pubmed/25387667
http://dx.doi.org/10.1590/1414-431X20144005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244666/
https://www.ncbi.nlm.nih.gov/pubmed/25387667
http://dx.doi.org/10.1590/1414-431X20144005

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