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DNA methylation regulates expression of VEGF-C, and S-adenosylmethionine is effective for VEGF-C methylation and for inhibiting cancer growth

DNA hypomethylation may activate oncogene transcription, thus promoting carcinogenesis and tumor development. S-adenosylmethionine (SAM) is a methyl donor in numerous methylation reactions and acts as an inhibitor of intracellular demethylase activity, which results in hypermethylation of DNA. The m...

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Detalles Bibliográficos
Autores principales:	Da, M.X., Zhang, Y.B., Yao, J.B., Duan, Y.X.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Associação Brasileira de Divulgação Científica 2014
Materias:	Biomedical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244666/ https://www.ncbi.nlm.nih.gov/pubmed/25387667 http://dx.doi.org/10.1590/1414-431X20144005

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