Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia

An inherited deficiency of the mitochondrial protein frataxin causes Friedreich's ataxia (FRDA); the mechanism by which this deficiency triggers neuro- and cardio-degeneration is unclear. Microarrays of neural tissue of animal models of the disease showed decreases in antioxidant genes, and inc...

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Detalles Bibliográficos
Autores principales: Hayashi, Genki, Shen, Yan, Pedersen, Theresa L., Newman, John W., Pook, Mark, Cortopassi, Gino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245045/
https://www.ncbi.nlm.nih.gov/pubmed/25104852
http://dx.doi.org/10.1093/hmg/ddu407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245045/
https://www.ncbi.nlm.nih.gov/pubmed/25104852
http://dx.doi.org/10.1093/hmg/ddu407

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