Small-Molecule Inhibitors of SETD8 with Cellular Activity

[Image: see text] SETD8/SET8/Pr-SET7/KMT5A is the sole protein lysine methyltransferase (PKMT) known to monomethylate lysine 20 of histone H4 in vivo. SETD8’s methyltransferase activity has been implicated in many essential cellular processes including DNA replication, DNA damage response, transcrip...

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Detalles Bibliográficos
Autores principales: Blum, Gil, Ibáñez, Glorymar, Rao, Xiangjun, Shum, David, Radu, Constantin, Djaballah, Hakim, Rice, Judd C., Luo, Minkui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245162/
https://www.ncbi.nlm.nih.gov/pubmed/25137013
http://dx.doi.org/10.1021/cb500515r

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245162/
https://www.ncbi.nlm.nih.gov/pubmed/25137013
http://dx.doi.org/10.1021/cb500515r

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