(−) Arctigenin and (+) Pinoresinol Are Antagonists of the Human Thyroid Hormone Receptor β

[Image: see text] Lignans are important biologically active dietary polyphenolic compounds. Consumption of foods that are rich in lignans is associated with positive health effects. Using modeling tools to probe the ligand-binding pockets of molecular receptors, we found that lignans have high docki...

Descripción completa

Detalles Bibliográficos
Autores principales: Ogungbe, Ifedayo Victor, Crouch, Rebecca A., Demeritte, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245177/
https://www.ncbi.nlm.nih.gov/pubmed/25383984
http://dx.doi.org/10.1021/ci500537e
_version_ 1782346326467411968
author Ogungbe, Ifedayo Victor
Crouch, Rebecca A.
Demeritte, Teresa
author_facet Ogungbe, Ifedayo Victor
Crouch, Rebecca A.
Demeritte, Teresa
author_sort Ogungbe, Ifedayo Victor
collection PubMed
description [Image: see text] Lignans are important biologically active dietary polyphenolic compounds. Consumption of foods that are rich in lignans is associated with positive health effects. Using modeling tools to probe the ligand-binding pockets of molecular receptors, we found that lignans have high docking affinity for the human thyroid hormone receptor β. Follow-up experimental results show that lignans (−) arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor β. The modeled complexes show key plausible interactions between the two ligands and important amino acid residues of the receptor.
format Online
Article
Text
id pubmed-4245177
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-42451772015-11-10 (−) Arctigenin and (+) Pinoresinol Are Antagonists of the Human Thyroid Hormone Receptor β Ogungbe, Ifedayo Victor Crouch, Rebecca A. Demeritte, Teresa J Chem Inf Model [Image: see text] Lignans are important biologically active dietary polyphenolic compounds. Consumption of foods that are rich in lignans is associated with positive health effects. Using modeling tools to probe the ligand-binding pockets of molecular receptors, we found that lignans have high docking affinity for the human thyroid hormone receptor β. Follow-up experimental results show that lignans (−) arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor β. The modeled complexes show key plausible interactions between the two ligands and important amino acid residues of the receptor. American Chemical Society 2014-11-10 2014-11-24 /pmc/articles/PMC4245177/ /pubmed/25383984 http://dx.doi.org/10.1021/ci500537e Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Ogungbe, Ifedayo Victor
Crouch, Rebecca A.
Demeritte, Teresa
(−) Arctigenin and (+) Pinoresinol Are Antagonists of the Human Thyroid Hormone Receptor β
title (−) Arctigenin and (+) Pinoresinol Are Antagonists of the Human Thyroid Hormone Receptor β
title_full (−) Arctigenin and (+) Pinoresinol Are Antagonists of the Human Thyroid Hormone Receptor β
title_fullStr (−) Arctigenin and (+) Pinoresinol Are Antagonists of the Human Thyroid Hormone Receptor β
title_full_unstemmed (−) Arctigenin and (+) Pinoresinol Are Antagonists of the Human Thyroid Hormone Receptor β
title_short (−) Arctigenin and (+) Pinoresinol Are Antagonists of the Human Thyroid Hormone Receptor β
title_sort (−) arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor β
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245177/
https://www.ncbi.nlm.nih.gov/pubmed/25383984
http://dx.doi.org/10.1021/ci500537e
work_keys_str_mv AT ogungbeifedayovictor arctigeninandpinoresinolareantagonistsofthehumanthyroidhormonereceptorb
AT crouchrebeccaa arctigeninandpinoresinolareantagonistsofthehumanthyroidhormonereceptorb
AT demeritteteresa arctigeninandpinoresinolareantagonistsofthehumanthyroidhormonereceptorb

Ejemplares similares