Advancements in the Development of HIF-1α-Activated Protein Switches for Use in Enzyme Prodrug Therapy

While gene-directed enzyme prodrug therapy has shown potential as a cancer therapeutic in animal and clinical trials, concerns over the efficacy, selectivity, and safety of gene delivery vehicles have restricted its advance. In an attempt to relieve some of the demands on targeted gene delivery vehi...

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Detalles Bibliográficos
Autores principales: Wright, R. Clay, Khakhar, Arjun, Eshleman, James R., Ostermeier, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245239/
https://www.ncbi.nlm.nih.gov/pubmed/25426963
http://dx.doi.org/10.1371/journal.pone.0114032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245239/
https://www.ncbi.nlm.nih.gov/pubmed/25426963
http://dx.doi.org/10.1371/journal.pone.0114032

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