Dimer-Dependent Intrinsic/Basal Activity of the Class B G Protein-Coupled Receptor PAC1 Promotes Cellular Anti-Apoptotic Activity through Wnt/β-Catenin Pathways that Are Associated with Dimer Endocytosis

The high expression of PACAP (pituitary adenylate cyclase-activating polypeptide)-preferring receptor PAC1 is associated with nerve injury and tumors. Our previous report (Yu R, et al. PLoS One 2012; 7: e51811) confirmed the dimerization of PAC1 and found that the M-PAC1 mutation in the N-terminal f...

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Detalles Bibliográficos
Autores principales: Yu, Rongjie, Cui, Zekai, Li, Mei, Yang, Yanxu, Zhong, Jiaping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245242/
https://www.ncbi.nlm.nih.gov/pubmed/25426938
http://dx.doi.org/10.1371/journal.pone.0113913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245242/
https://www.ncbi.nlm.nih.gov/pubmed/25426938
http://dx.doi.org/10.1371/journal.pone.0113913

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