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Deficits in memory-guided limb movements impair obstacle avoidance locomotion in Alzheimer's disease mouse model

Memory function deficits induced by Alzheimer's disease (AD) are believed to be one of the causes of an increased risk of tripping in patients. Working memory contributes to accurate stepping over obstacles during locomotion, and AD-induced deficits of this memory function may lead to an increa...

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Autores principales: Setogawa, Susumu, Yamaura, Hiroshi, Arasaki, Tomoko, Endo, Shogo, Yanagihara, Dai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245527/
https://www.ncbi.nlm.nih.gov/pubmed/25427820
http://dx.doi.org/10.1038/srep07220
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author Setogawa, Susumu
Yamaura, Hiroshi
Arasaki, Tomoko
Endo, Shogo
Yanagihara, Dai
author_facet Setogawa, Susumu
Yamaura, Hiroshi
Arasaki, Tomoko
Endo, Shogo
Yanagihara, Dai
author_sort Setogawa, Susumu
collection PubMed
description Memory function deficits induced by Alzheimer's disease (AD) are believed to be one of the causes of an increased risk of tripping in patients. Working memory contributes to accurate stepping over obstacles during locomotion, and AD-induced deficits of this memory function may lead to an increased risk of contact with obstacles. We used the triple transgenic (3xTg) mice to examine the effects of memory deficits in terms of tripping and contact with obstacles. We found that the frequency of contact of the hindlimbs during an obstacle avoidance task increased significantly in 10–13 month-old 3xTg (Old-3xTg) mice compared with control mice. However, no changes in limb kinematics during unobstructed locomotion or successful obstacle avoidance locomotion were observed in the Old-3xTg mice. Furthermore, we found that memory-based movements in stepping over an obstacle were impaired in these mice. Our findings suggest that working memory deficits as a result of AD are associated with an increased risk of tripping during locomotion.
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spelling pubmed-42455272014-12-05 Deficits in memory-guided limb movements impair obstacle avoidance locomotion in Alzheimer's disease mouse model Setogawa, Susumu Yamaura, Hiroshi Arasaki, Tomoko Endo, Shogo Yanagihara, Dai Sci Rep Article Memory function deficits induced by Alzheimer's disease (AD) are believed to be one of the causes of an increased risk of tripping in patients. Working memory contributes to accurate stepping over obstacles during locomotion, and AD-induced deficits of this memory function may lead to an increased risk of contact with obstacles. We used the triple transgenic (3xTg) mice to examine the effects of memory deficits in terms of tripping and contact with obstacles. We found that the frequency of contact of the hindlimbs during an obstacle avoidance task increased significantly in 10–13 month-old 3xTg (Old-3xTg) mice compared with control mice. However, no changes in limb kinematics during unobstructed locomotion or successful obstacle avoidance locomotion were observed in the Old-3xTg mice. Furthermore, we found that memory-based movements in stepping over an obstacle were impaired in these mice. Our findings suggest that working memory deficits as a result of AD are associated with an increased risk of tripping during locomotion. Nature Publishing Group 2014-11-27 /pmc/articles/PMC4245527/ /pubmed/25427820 http://dx.doi.org/10.1038/srep07220 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Article
Setogawa, Susumu
Yamaura, Hiroshi
Arasaki, Tomoko
Endo, Shogo
Yanagihara, Dai
Deficits in memory-guided limb movements impair obstacle avoidance locomotion in Alzheimer's disease mouse model
title Deficits in memory-guided limb movements impair obstacle avoidance locomotion in Alzheimer's disease mouse model
title_full Deficits in memory-guided limb movements impair obstacle avoidance locomotion in Alzheimer's disease mouse model
title_fullStr Deficits in memory-guided limb movements impair obstacle avoidance locomotion in Alzheimer's disease mouse model
title_full_unstemmed Deficits in memory-guided limb movements impair obstacle avoidance locomotion in Alzheimer's disease mouse model
title_short Deficits in memory-guided limb movements impair obstacle avoidance locomotion in Alzheimer's disease mouse model
title_sort deficits in memory-guided limb movements impair obstacle avoidance locomotion in alzheimer's disease mouse model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245527/
https://www.ncbi.nlm.nih.gov/pubmed/25427820
http://dx.doi.org/10.1038/srep07220
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