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Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation

Inflammation, as indicated by C-reactive protein concentrations (CRP), is a risk factor for chronic diseases. Both genetic and environmental factors affect susceptibility to inflammation. As dietary interventions can influence inflammatory status, we hypothesized that dietary effects could be influe...

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Autores principales: Nienaber-Rousseau, Cornelie, Swanepoel, Bianca, Dolman, Robin C., Pieters, Marlien, Conradie, Karin R., Towers, G. Wayne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245578/
https://www.ncbi.nlm.nih.gov/pubmed/25393688
http://dx.doi.org/10.3390/nu6115034
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author Nienaber-Rousseau, Cornelie
Swanepoel, Bianca
Dolman, Robin C.
Pieters, Marlien
Conradie, Karin R.
Towers, G. Wayne
author_facet Nienaber-Rousseau, Cornelie
Swanepoel, Bianca
Dolman, Robin C.
Pieters, Marlien
Conradie, Karin R.
Towers, G. Wayne
author_sort Nienaber-Rousseau, Cornelie
collection PubMed
description Inflammation, as indicated by C-reactive protein concentrations (CRP), is a risk factor for chronic diseases. Both genetic and environmental factors affect susceptibility to inflammation. As dietary interventions can influence inflammatory status, we hypothesized that dietary effects could be influenced by interactions with single nucleotide polymorphisms (SNPs) in the CRP gene. We determined 12 CRP SNPs, as well as various nutrition status markers in 2010 black South Africans and analyzed their effect on CRP. Interactions were observed for several genotypes with obesity in determining CRP. Lipid intake modulated the pro-inflammatory effects of some SNPs, i.e., an increase in both saturated fatty acid and monounsaturated fatty acid intake in those homozygous for the polymorphic allele at rs2808630 was associated with a larger increase in CRP. Those harboring the minor alleles at rs3093058 and rs3093062 presented with significantly higher CRP in the presence of increased triglyceride or cholesterol intake. When harboring the minor allele of these SNPs, a high omega-6 to -3 ratio was, however, found to be anti-inflammatory. Carbohydrate intake also modulated CRP SNPs, as HbA1C and fasting glucose levels interacted with some SNPs to influence the CRP. This investigation highlights the impact that nutritional status can have on reducing the inherent genetic susceptibility to a heightened systemic inflammatory state.
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spelling pubmed-42455782014-12-01 Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation Nienaber-Rousseau, Cornelie Swanepoel, Bianca Dolman, Robin C. Pieters, Marlien Conradie, Karin R. Towers, G. Wayne Nutrients Article Inflammation, as indicated by C-reactive protein concentrations (CRP), is a risk factor for chronic diseases. Both genetic and environmental factors affect susceptibility to inflammation. As dietary interventions can influence inflammatory status, we hypothesized that dietary effects could be influenced by interactions with single nucleotide polymorphisms (SNPs) in the CRP gene. We determined 12 CRP SNPs, as well as various nutrition status markers in 2010 black South Africans and analyzed their effect on CRP. Interactions were observed for several genotypes with obesity in determining CRP. Lipid intake modulated the pro-inflammatory effects of some SNPs, i.e., an increase in both saturated fatty acid and monounsaturated fatty acid intake in those homozygous for the polymorphic allele at rs2808630 was associated with a larger increase in CRP. Those harboring the minor alleles at rs3093058 and rs3093062 presented with significantly higher CRP in the presence of increased triglyceride or cholesterol intake. When harboring the minor allele of these SNPs, a high omega-6 to -3 ratio was, however, found to be anti-inflammatory. Carbohydrate intake also modulated CRP SNPs, as HbA1C and fasting glucose levels interacted with some SNPs to influence the CRP. This investigation highlights the impact that nutritional status can have on reducing the inherent genetic susceptibility to a heightened systemic inflammatory state. MDPI 2014-11-11 /pmc/articles/PMC4245578/ /pubmed/25393688 http://dx.doi.org/10.3390/nu6115034 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nienaber-Rousseau, Cornelie
Swanepoel, Bianca
Dolman, Robin C.
Pieters, Marlien
Conradie, Karin R.
Towers, G. Wayne
Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation
title Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation
title_full Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation
title_fullStr Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation
title_full_unstemmed Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation
title_short Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation
title_sort interactions between c-reactive protein genotypes with markers of nutritional status in relation to inflammation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245578/
https://www.ncbi.nlm.nih.gov/pubmed/25393688
http://dx.doi.org/10.3390/nu6115034
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