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Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation
Inflammation, as indicated by C-reactive protein concentrations (CRP), is a risk factor for chronic diseases. Both genetic and environmental factors affect susceptibility to inflammation. As dietary interventions can influence inflammatory status, we hypothesized that dietary effects could be influe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245578/ https://www.ncbi.nlm.nih.gov/pubmed/25393688 http://dx.doi.org/10.3390/nu6115034 |
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author | Nienaber-Rousseau, Cornelie Swanepoel, Bianca Dolman, Robin C. Pieters, Marlien Conradie, Karin R. Towers, G. Wayne |
author_facet | Nienaber-Rousseau, Cornelie Swanepoel, Bianca Dolman, Robin C. Pieters, Marlien Conradie, Karin R. Towers, G. Wayne |
author_sort | Nienaber-Rousseau, Cornelie |
collection | PubMed |
description | Inflammation, as indicated by C-reactive protein concentrations (CRP), is a risk factor for chronic diseases. Both genetic and environmental factors affect susceptibility to inflammation. As dietary interventions can influence inflammatory status, we hypothesized that dietary effects could be influenced by interactions with single nucleotide polymorphisms (SNPs) in the CRP gene. We determined 12 CRP SNPs, as well as various nutrition status markers in 2010 black South Africans and analyzed their effect on CRP. Interactions were observed for several genotypes with obesity in determining CRP. Lipid intake modulated the pro-inflammatory effects of some SNPs, i.e., an increase in both saturated fatty acid and monounsaturated fatty acid intake in those homozygous for the polymorphic allele at rs2808630 was associated with a larger increase in CRP. Those harboring the minor alleles at rs3093058 and rs3093062 presented with significantly higher CRP in the presence of increased triglyceride or cholesterol intake. When harboring the minor allele of these SNPs, a high omega-6 to -3 ratio was, however, found to be anti-inflammatory. Carbohydrate intake also modulated CRP SNPs, as HbA1C and fasting glucose levels interacted with some SNPs to influence the CRP. This investigation highlights the impact that nutritional status can have on reducing the inherent genetic susceptibility to a heightened systemic inflammatory state. |
format | Online Article Text |
id | pubmed-4245578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42455782014-12-01 Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation Nienaber-Rousseau, Cornelie Swanepoel, Bianca Dolman, Robin C. Pieters, Marlien Conradie, Karin R. Towers, G. Wayne Nutrients Article Inflammation, as indicated by C-reactive protein concentrations (CRP), is a risk factor for chronic diseases. Both genetic and environmental factors affect susceptibility to inflammation. As dietary interventions can influence inflammatory status, we hypothesized that dietary effects could be influenced by interactions with single nucleotide polymorphisms (SNPs) in the CRP gene. We determined 12 CRP SNPs, as well as various nutrition status markers in 2010 black South Africans and analyzed their effect on CRP. Interactions were observed for several genotypes with obesity in determining CRP. Lipid intake modulated the pro-inflammatory effects of some SNPs, i.e., an increase in both saturated fatty acid and monounsaturated fatty acid intake in those homozygous for the polymorphic allele at rs2808630 was associated with a larger increase in CRP. Those harboring the minor alleles at rs3093058 and rs3093062 presented with significantly higher CRP in the presence of increased triglyceride or cholesterol intake. When harboring the minor allele of these SNPs, a high omega-6 to -3 ratio was, however, found to be anti-inflammatory. Carbohydrate intake also modulated CRP SNPs, as HbA1C and fasting glucose levels interacted with some SNPs to influence the CRP. This investigation highlights the impact that nutritional status can have on reducing the inherent genetic susceptibility to a heightened systemic inflammatory state. MDPI 2014-11-11 /pmc/articles/PMC4245578/ /pubmed/25393688 http://dx.doi.org/10.3390/nu6115034 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nienaber-Rousseau, Cornelie Swanepoel, Bianca Dolman, Robin C. Pieters, Marlien Conradie, Karin R. Towers, G. Wayne Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation |
title | Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation |
title_full | Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation |
title_fullStr | Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation |
title_full_unstemmed | Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation |
title_short | Interactions between C-Reactive Protein Genotypes with Markers of Nutritional Status in Relation to Inflammation |
title_sort | interactions between c-reactive protein genotypes with markers of nutritional status in relation to inflammation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245578/ https://www.ncbi.nlm.nih.gov/pubmed/25393688 http://dx.doi.org/10.3390/nu6115034 |
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