Conversion of Substrate Analogs Suggests a Michael Cyclization in Iridoid Biosynthesis

The core structure of the iridoid monoterpenes is formed by a unique cyclization reaction. The enzyme that catalyzes this reaction, iridoid synthase, is mechanistically distinct from other terpene cyclases. Here we describe the synthesis of two substrate analogs to probe the mechanism of iridoid syn...

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Detalles Bibliográficos
Autores principales: Lindner, Stephanie, Geu-Flores, Fernando, Bräse, Stefan, Sherden, Nathaniel H., O’Connor, Sarah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245709/
https://www.ncbi.nlm.nih.gov/pubmed/25444551
http://dx.doi.org/10.1016/j.chembiol.2014.09.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245709/
https://www.ncbi.nlm.nih.gov/pubmed/25444551
http://dx.doi.org/10.1016/j.chembiol.2014.09.010

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