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Conversion of Substrate Analogs Suggests a Michael Cyclization in Iridoid Biosynthesis
The core structure of the iridoid monoterpenes is formed by a unique cyclization reaction. The enzyme that catalyzes this reaction, iridoid synthase, is mechanistically distinct from other terpene cyclases. Here we describe the synthesis of two substrate analogs to probe the mechanism of iridoid syn...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245709/ https://www.ncbi.nlm.nih.gov/pubmed/25444551 http://dx.doi.org/10.1016/j.chembiol.2014.09.010 |