Synergistic modulation of cyclobutane pyrimidine dimer photoproduct formation and deamination at a T(m)CG site over a full helical DNA turn in a nucleosome core particle

Sunlight-induced C to T mutation hotspots in skin cancers occur primarily at methylated CpG sites that coincide with sites of UV-induced cyclobutane pyrimidine dimer (CPD) formation. The C or 5-methyl-C in CPDs are not stable and deaminate to U and T, respectively, which leads to the insertion of A...

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Detalles Bibliográficos
Autores principales: Song, Qian, Cannistraro, Vincent J., Taylor, John-Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245940/
https://www.ncbi.nlm.nih.gov/pubmed/25389265
http://dx.doi.org/10.1093/nar/gku1049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245940/
https://www.ncbi.nlm.nih.gov/pubmed/25389265
http://dx.doi.org/10.1093/nar/gku1049

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