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Timely binding of IHF and Fis to DARS2 regulates ATP–DnaA production and replication initiation
In Escherichia coli, the ATP-bound form of DnaA (ATP–DnaA) promotes replication initiation. During replication, the bound ATP is hydrolyzed to ADP to yield the ADP-bound form (ADP–DnaA), which is inactive for initiation. The chromosomal site DARS2 facilitates the regeneration of ATP–DnaA by catalyzi...
Autores principales: | Kasho, Kazutoshi, Fujimitsu, Kazuyuki, Matoba, Toshihiro, Oshima, Taku, Katayama, Tsutomu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245941/ https://www.ncbi.nlm.nih.gov/pubmed/25378325 http://dx.doi.org/10.1093/nar/gku1051 |
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