Structural and biochemical impact of C8-aryl-guanine adducts within the NarI recognition DNA sequence: influence of aryl ring size on targeted and semi-targeted mutagenicity

Chemical mutagens with an aromatic ring system may be enzymatically transformed to afford aryl radical species that preferentially react at the C8-site of 2′-deoxyguanosine (dG). The resulting carbon-linked C8-aryl-dG adduct possesses altered biophysical and genetic coding properties compared to the...

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Detalles Bibliográficos
Autores principales: Sproviero, Michael, Verwey, Anne M.R., Rankin, Katherine M., Witham, Aaron A., Soldatov, Dmitriy V., Manderville, Richard A., Fekry, Mostafa I., Sturla, Shana J., Sharma, Purshotam, Wetmore, Stacey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245952/
https://www.ncbi.nlm.nih.gov/pubmed/25361967
http://dx.doi.org/10.1093/nar/gku1093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245952/
https://www.ncbi.nlm.nih.gov/pubmed/25361967
http://dx.doi.org/10.1093/nar/gku1093

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