Cargando…

A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function

BRCA1 is involved in many disparate cellular functions, including DNA damage repair, cell-cycle checkpoint activation, gene transcriptional regulation, DNA replication, centrosome function and others. The majority of evidence strongly favors the maintenance of genomic integrity as a principal tumor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kononenko, Artem V., Bansal, Ruchi, Lee, Nicholas C.O., Grimes, Brenda R., Masumoto, Hiroshi, Earnshaw, William C., Larionov, Vladimir, Kouprina, Natalay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245969/ https://www.ncbi.nlm.nih.gov/pubmed/25260588 http://dx.doi.org/10.1093/nar/gku870

Ejemplares similares

Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTA(VP64) expression cassette
por: Kononenko, Artem V., et al.
Publicado: (2015)

Re-engineering an alphoid(tetO)-HAC-based vector to enable high-throughput analyses of gene function
por: Kononenko, Artem V., et al.
Publicado: (2013)

Protecting a transgene expression from the HAC-based vector by different chromatin insulators
por: Lee, Nicholas CO, et al.
Publicado: (2013)

Highly efficient CRISPR/Cas9-mediated TAR cloning of genes and chromosomal loci from complex genomes in yeast
por: Lee, Nicholas C.O., et al.
Publicado: (2015)

A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells
por: Lee, Hee-Sheung, et al.
Publicado: (2013)

Analysis of Complex DNA Rearrangements during Early Stages of HAC Formation
por: Pesenti, Elisa, et al.
Publicado: (2020)

Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly
por: Ohzeki, Jun-ichirou, et al.
Publicado: (2012)

Rapid generation of long synthetic tandem repeats and its application for analysis in human artificial chromosome formation
por: Ebersole, Tom, et al.
Publicado: (2005)

Novel screen for anti-cancer drugs that elevate chromosome instability (CIN) using human artificial chromosome (HAC)
por: Kouprina, Natalay, et al.
Publicado: (2018)

Development of a novel HAC-based “gain of signal” quantitative assay for measuring chromosome instability (CIN) in cancer cells
por: Kim, Jung-Hyun, et al.
Publicado: (2016)

Nucleotide resolution profiling of m(3)C RNA modification by HAC-seq
por: Cui, Jia, et al.
Publicado: (2020)

Selective nanopore sequencing of human BRCA1 by Cas9-assisted targeting of chromosome segments (CATCH)
por: Gabrieli, Tslil, et al.
Publicado: (2018)

A novel assay to screen siRNA libraries identifies protein kinases required for chromosome transmission
por: Liskovykh, Mikhail, et al.
Publicado: (2019)

BRCA1 and BRCA2 Tumor Suppressor Function in Meiosis
por: Li, Qianyan, et al.
Publicado: (2021)

Novel BRCA1 and BRCA2 Tumor Test as Basis for Treatment Decisions and Referral for Genetic Counselling of Patients with Ovarian Carcinomas
por: Weren, Robbert D.A., et al.
Publicado: (2016)

Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies
por: Pesenti, Elisa, et al.
Publicado: (2018)

Moving toward a higher efficiency of microcell-mediated chromosome transfer
por: Liskovykh, Mikhail, et al.
Publicado: (2016)

Rapid generation of long tandem DNA repeat arrays by homologous recombination in yeast to study their function in mammalian genomes
por: Noskov, Vladimir N, et al.
Publicado: (2011)

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity
por: Tacconi, Eliana MC, et al.
Publicado: (2017)

Structure-Function of the Tumor Suppressor BRCA1
por: Clark, Serena L., et al.
Publicado: (2012)

Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies
por: Kouprina, Natalay, et al.
Publicado: (2018)

Method to Assemble Genomic DNA Fragments or Genes on Human Artificial Chromosome with Regulated Kinetochore Using a Multi-Integrase System
por: Lee, Nicholas C. O., et al.
Publicado: (2017)

Recent advances in chromosome engineering
por: Kouprina, Natalay, et al.
Publicado: (2015)

TAR Cloning: Perspectives for Functional Genomics, Biomedicine, and Biotechnology
por: Kouprina, Natalay, et al.
Publicado: (2019)

Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance
por: Molina, Oscar, et al.
Publicado: (2016)

Actively transcribed rDNA and distal junction (DJ) sequence are involved in association of NORs with nucleoli
por: Liskovykh, Mikhail, et al.
Publicado: (2023)

3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin
por: Booth, Daniel G., et al.
Publicado: (2016)

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells
por: Petrov, Nikolai, et al.
Publicado: (2021)

BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development
por: Kitami, Kohei, et al.
Publicado: (2018)

A small, portable RNA device for the control of exon skipping in mammalian cells
por: Vogel, Marc, et al.
Publicado: (2018)

Affinity maturation of a portable Fab–RNA module for chaperone-assisted RNA crystallography
por: Koirala, Deepak, et al.
Publicado: (2018)

BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2
por: Cline, Melissa S., et al.
Publicado: (2018)

Engineering a portable riboswitch-LacP hybrid device for two-way gene regulation
por: Jin, Ye, et al.
Publicado: (2011)

Presymptomatic breast cancer in Egypt: role of BRCA1 and BRCA2 tumor suppressor genes mutations detection
por: Ibrahim, Safinaz S, et al.
Publicado: (2010)

BRCA1 tumor suppressor network: focusing on its tail
por: Wang, Bin
Publicado: (2012)

BRCA1 as tumor suppressor: lord without its RING?
por: Elia, Andrew EH, et al.
Publicado: (2012)

Uncovering the Translational Regulatory Activity of the Tumor Suppressor BRCA1
por: Berthel, Elise, et al.
Publicado: (2020)

Prediction of the functional impact of missense variants in BRCA1 and BRCA2 with BRCA-ML
por: Hart, Steven N., et al.
Publicado: (2020)

Deep sequencing-based expression analysis shows major advances in robustness, resolution and inter-lab portability over five microarray platforms
por: 't Hoen, Peter A. C., et al.
Publicado: (2008)

Retarding breast tumor growth with nanoparticle-facilitated intravenous delivery of BRCA1 and BRCA2 tumor suppressor genes
por: Ibnat, Nabilah, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fe9t3aqofknecaef2ervjkla80