A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function
BRCA1 is involved in many disparate cellular functions, including DNA damage repair, cell-cycle checkpoint activation, gene transcriptional regulation, DNA replication, centrosome function and others. The majority of evidence strongly favors the maintenance of genomic integrity as a principal tumor...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245969/ https://www.ncbi.nlm.nih.gov/pubmed/25260588 http://dx.doi.org/10.1093/nar/gku870 |