X-ray Structure of a Hg(2+) Complex of Mercuric Reductase (MerA) and Quantum Mechanical/Molecular Mechanical Study of Hg(2+) Transfer between the C-Terminal and Buried Catalytic Site Cysteine Pairs

[Image: see text] Mercuric reductase, MerA, is a key enzyme in bacterial mercury resistance. This homodimeric enzyme captures and reduces toxic Hg(2+) to Hg(0), which is relatively unreactive and can exit the cell passively. Prior to reduction, the Hg(2+) is transferred from a pair of cysteines (C55...

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Detalles Bibliográficos
Autores principales: Lian, Peng, Guo, Hao-Bo, Riccardi, Demian, Dong, Aiping, Parks, Jerry M., Xu, Qin, Pai, Emil F., Miller, Susan M., Wei, Dong-Qing, Smith, Jeremy C., Guo, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245977/
https://www.ncbi.nlm.nih.gov/pubmed/25343681
http://dx.doi.org/10.1021/bi500608u

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245977/
https://www.ncbi.nlm.nih.gov/pubmed/25343681
http://dx.doi.org/10.1021/bi500608u

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