Assessing Proteinase K Resistance of Fish Prion Proteins in a Scrapie-Infected Mouse Neuroblastoma Cell Line

The key event in prion pathogenesis is the structural conversion of the normal cellular protein, PrP(C), into an aberrant and partially proteinase K resistant isoform, PrP(Sc). Since the minimum requirement for a prion disease phenotype is the expression of endogenous PrP in the host, species carryi...

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Detalles Bibliográficos
Autores principales: Salta, Evgenia, Kanata, Eirini, Ouzounis, Christos A., Gilch, Sabine, Schätzl, Hermann, Sklaviadis, Theodoros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246229/
https://www.ncbi.nlm.nih.gov/pubmed/25402173
http://dx.doi.org/10.3390/v6114398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246229/
https://www.ncbi.nlm.nih.gov/pubmed/25402173
http://dx.doi.org/10.3390/v6114398

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