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Assessing Proteinase K Resistance of Fish Prion Proteins in a Scrapie-Infected Mouse Neuroblastoma Cell Line

The key event in prion pathogenesis is the structural conversion of the normal cellular protein, PrP(C), into an aberrant and partially proteinase K resistant isoform, PrP(Sc). Since the minimum requirement for a prion disease phenotype is the expression of endogenous PrP in the host, species carryi...

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Detalles Bibliográficos
Autores principales:	Salta, Evgenia, Kanata, Eirini, Ouzounis, Christos A., Gilch, Sabine, Schätzl, Hermann, Sklaviadis, Theodoros
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246229/ https://www.ncbi.nlm.nih.gov/pubmed/25402173 http://dx.doi.org/10.3390/v6114398

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