Physiological levels of lipoxin A(4) inhibit ENaC and restore airway surface liquid height in cystic fibrosis bronchial epithelium

In cystic fibrosis (CF), the airway surface liquid (ASL) is depleted. We previously demonstrated that lipoxin A(4) (LXA(4)) can modulate ASL height (ASLh) through actions on Cl(−) transport. Here, we report novel effects of lipoxin on the epithelial Na(+) channel ENaC in this response. ASL dynamics...

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Detalles Bibliográficos
Autores principales: Al‐Alawi, Mazen, Buchanan, Paul, Verriere, Valia, Higgins, Gerard, McCabe, Olive, Costello, Richard W., McNally, Paul, Urbach, Valérie, Harvey, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246599/
https://www.ncbi.nlm.nih.gov/pubmed/25107986
http://dx.doi.org/10.14814/phy2.12093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246599/
https://www.ncbi.nlm.nih.gov/pubmed/25107986
http://dx.doi.org/10.14814/phy2.12093

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