A Genetic Variant of p53 Restricts the Mucus Secretory Phenotype by Regulating SPDEF and Bcl-2 Expression

Despite implications for carcinogenesis and other chronic diseases, basic mechanisms of p53 and its variants in suppressing Bcl-2 levels, are poorly understood. Bcl-2 sustains mucous cell metaplasia, whereas p53(−/−) mice display chronically increased mucous cells. Here we show that p53 decreases bc...

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Detalles Bibliográficos
Autores principales: Chand, Hitendra S., Montano, Gilbert, Huang, Xuesong, Randell, Scott H., Mebratu, Yohannes, Petersen, Hans, Tesfaigzi, Yohannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247165/
https://www.ncbi.nlm.nih.gov/pubmed/25429397
http://dx.doi.org/10.1038/ncomms6567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247165/
https://www.ncbi.nlm.nih.gov/pubmed/25429397
http://dx.doi.org/10.1038/ncomms6567

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