Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria

Caspase-11 contributes to host defense against Gram-negative bacterial pathogens by inducing an inflammatory form of programmed cell death in infected cells. Lipopolysaccharides (LPS) have been identified as the microbial agents that stimulate caspase-11 activation; however, the mechanism of LPS det...

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Detalles Bibliográficos
Autores principales: Demon, Dieter, Vande Walle, Lieselotte, Lamkanfi, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Trends Journals 2014
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247376/
https://www.ncbi.nlm.nih.gov/pubmed/25458607
http://dx.doi.org/10.1016/j.tibs.2014.10.006
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author Demon, Dieter
Vande Walle, Lieselotte
Lamkanfi, Mohamed
author_facet Demon, Dieter
Vande Walle, Lieselotte
Lamkanfi, Mohamed
author_sort Demon, Dieter
collection PubMed
description Caspase-11 contributes to host defense against Gram-negative bacterial pathogens by inducing an inflammatory form of programmed cell death in infected cells. Lipopolysaccharides (LPS) have been identified as the microbial agents that stimulate caspase-11 activation; however, the mechanism of LPS detection has been unknown. In a recent study, Shao and colleagues demonstrate that caspase-11 and its human homologues, caspases -4 and -5, unexpectedly act as direct sensors of cytosolic LPS.
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spelling pubmed-42473762014-12-03 Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria Demon, Dieter Vande Walle, Lieselotte Lamkanfi, Mohamed Trends Biochem Sci Spotlight Caspase-11 contributes to host defense against Gram-negative bacterial pathogens by inducing an inflammatory form of programmed cell death in infected cells. Lipopolysaccharides (LPS) have been identified as the microbial agents that stimulate caspase-11 activation; however, the mechanism of LPS detection has been unknown. In a recent study, Shao and colleagues demonstrate that caspase-11 and its human homologues, caspases -4 and -5, unexpectedly act as direct sensors of cytosolic LPS. Elsevier Trends Journals 2014-12 /pmc/articles/PMC4247376/ /pubmed/25458607 http://dx.doi.org/10.1016/j.tibs.2014.10.006 Text en © 2014 The Authors https://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Spotlight
Demon, Dieter
Vande Walle, Lieselotte
Lamkanfi, Mohamed
Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria
title Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria
title_full Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria
title_fullStr Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria
title_full_unstemmed Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria
title_short Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria
title_sort sensing the enemy within: how macrophages detect intracellular gram-negative bacteria
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247376/
https://www.ncbi.nlm.nih.gov/pubmed/25458607
http://dx.doi.org/10.1016/j.tibs.2014.10.006
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