Dysregulation of SIRT-1 in aging mice increases skeletal muscle fatigue by a PARP-1-dependent mechanism

Accumulation of reactive oxygen species (ROS) in skeletal muscles and the resulting decline in muscle performance are hallmarks of sarcopenia. However, the precise mechanism by which ROS results in a decline in muscle performance is unclear. We demonstrate that isometric-exercise concomitantly incre...

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Detalles Bibliográficos
Autores principales: Mohamed, Junaith S., Wilson, Joseph C., Myers, Matthew J., Sisson, Kayla J., Alway, Stephen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247385/
https://www.ncbi.nlm.nih.gov/pubmed/25361036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247385/
https://www.ncbi.nlm.nih.gov/pubmed/25361036

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