Lymph node characteristics of sarcoidosis with endobronchial ultrasound

BACKGROUND: Sonographic features of lymph nodes on endobronchial ultrasound (EBUS) have been shown to be useful in prediction of malignancy in mediastinum and hilum. The aim of this study was to assess the utility of morphologic features of mediastinal and/or hilar lymph nodes obtained by EBUS in pa...

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Autores principales: Ozgul, Mehmet Akif, Cetinkaya, Erdoğan, Kirkil, Gamze, Ozgul, Guler, Abul, Yasin, Acat, Murat, Onaran, Hilal, Urer, Halide Nur, Tutar, Nuri, Dincer, H. Erhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247531/
https://www.ncbi.nlm.nih.gov/pubmed/25485271
http://dx.doi.org/10.4103/2303-9027.144541
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author Ozgul, Mehmet Akif
Cetinkaya, Erdoğan
Kirkil, Gamze
Ozgul, Guler
Abul, Yasin
Acat, Murat
Onaran, Hilal
Urer, Halide Nur
Tutar, Nuri
Dincer, H. Erhan
author_facet Ozgul, Mehmet Akif
Cetinkaya, Erdoğan
Kirkil, Gamze
Ozgul, Guler
Abul, Yasin
Acat, Murat
Onaran, Hilal
Urer, Halide Nur
Tutar, Nuri
Dincer, H. Erhan
author_sort Ozgul, Mehmet Akif
collection PubMed
description BACKGROUND: Sonographic features of lymph nodes on endobronchial ultrasound (EBUS) have been shown to be useful in prediction of malignancy in mediastinum and hilum. The aim of this study was to assess the utility of morphologic features of mediastinal and/or hilar lymph nodes obtained by EBUS in patients with sarcoidosis. MATERIALS AND METHODS: We retrospectively reviewed the records of 224 patients with mediastinal/hilar lymph node enlargements who underwent EBUS for diagnostic purpose. The lymph nodes were characterized based on the EBUS images as follows: (1) Size; based on short-axis dimension, <1 cm or ≥1 cm, (2) shape; oval or round, (3) margin; distinct or indistinct, (4) echogenicity; homogeneous or heterogeneous, (5) presence or absence of central hilar structure, and (6) presence or absence of granular (sandpaper) appearance. RESULTS: One hundred (24.4%) nodes exhibited indistinct margins while 309 (75.6%) had distinct margins. One hundred and ninety nine (48.7%) nodes were characterized as homogeneous, and 210 (51.3%) nodes as heterogeneous. Granular appearance was observed in 130 (31.8%) lymph nodes. The presence of granules in lymph nodes on EBUS had the highest specificity (99.3%) for the diagnosis of sarcoidosis. Logistic regression analysis revealed the finding of distinct margin alone as an independent predictive factor for the diagnosis of sarcoidosis. CONCLUSIONS: The presence of granular appearance in lymph nodes by EBUS had the highest specificity (99.3%) for the diagnosis of sarcoidosis. Lymph nodes having distinct margins tend to suggest sarcoidosis.
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spelling pubmed-42475312014-12-05 Lymph node characteristics of sarcoidosis with endobronchial ultrasound Ozgul, Mehmet Akif Cetinkaya, Erdoğan Kirkil, Gamze Ozgul, Guler Abul, Yasin Acat, Murat Onaran, Hilal Urer, Halide Nur Tutar, Nuri Dincer, H. Erhan Endosc Ultrasound Original Article BACKGROUND: Sonographic features of lymph nodes on endobronchial ultrasound (EBUS) have been shown to be useful in prediction of malignancy in mediastinum and hilum. The aim of this study was to assess the utility of morphologic features of mediastinal and/or hilar lymph nodes obtained by EBUS in patients with sarcoidosis. MATERIALS AND METHODS: We retrospectively reviewed the records of 224 patients with mediastinal/hilar lymph node enlargements who underwent EBUS for diagnostic purpose. The lymph nodes were characterized based on the EBUS images as follows: (1) Size; based on short-axis dimension, <1 cm or ≥1 cm, (2) shape; oval or round, (3) margin; distinct or indistinct, (4) echogenicity; homogeneous or heterogeneous, (5) presence or absence of central hilar structure, and (6) presence or absence of granular (sandpaper) appearance. RESULTS: One hundred (24.4%) nodes exhibited indistinct margins while 309 (75.6%) had distinct margins. One hundred and ninety nine (48.7%) nodes were characterized as homogeneous, and 210 (51.3%) nodes as heterogeneous. Granular appearance was observed in 130 (31.8%) lymph nodes. The presence of granules in lymph nodes on EBUS had the highest specificity (99.3%) for the diagnosis of sarcoidosis. Logistic regression analysis revealed the finding of distinct margin alone as an independent predictive factor for the diagnosis of sarcoidosis. CONCLUSIONS: The presence of granular appearance in lymph nodes by EBUS had the highest specificity (99.3%) for the diagnosis of sarcoidosis. Lymph nodes having distinct margins tend to suggest sarcoidosis. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4247531/ /pubmed/25485271 http://dx.doi.org/10.4103/2303-9027.144541 Text en Copyright: © Endoscopic Ultrasound http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ozgul, Mehmet Akif
Cetinkaya, Erdoğan
Kirkil, Gamze
Ozgul, Guler
Abul, Yasin
Acat, Murat
Onaran, Hilal
Urer, Halide Nur
Tutar, Nuri
Dincer, H. Erhan
Lymph node characteristics of sarcoidosis with endobronchial ultrasound
title Lymph node characteristics of sarcoidosis with endobronchial ultrasound
title_full Lymph node characteristics of sarcoidosis with endobronchial ultrasound
title_fullStr Lymph node characteristics of sarcoidosis with endobronchial ultrasound
title_full_unstemmed Lymph node characteristics of sarcoidosis with endobronchial ultrasound
title_short Lymph node characteristics of sarcoidosis with endobronchial ultrasound
title_sort lymph node characteristics of sarcoidosis with endobronchial ultrasound
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247531/
https://www.ncbi.nlm.nih.gov/pubmed/25485271
http://dx.doi.org/10.4103/2303-9027.144541
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