Cargando…
Enhanced behavioral responses to cold stimuli following CGRPα sensory neuron ablation are dependent on TRPM8
BACKGROUND: Calcitonin gene-related peptide-α (CGRPα) is a classic marker of peptidergic nociceptive neurons and is expressed in myelinated and unmyelinated dorsal root ganglia (DRG) neurons. Recently, we found that ablation of Cgrpα-expressing sensory neurons reduced noxious heat sensitivity and en...
Autores principales: | McCoy, Eric S, Zylka, Mark J |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247560/ https://www.ncbi.nlm.nih.gov/pubmed/25406633 http://dx.doi.org/10.1186/1744-8069-10-69 |
Ejemplares similares
-
CGRPα-Expressing Sensory Neurons Respond to Stimuli that Evoke Sensations of Pain and Itch
por: McCoy, Eric S., et al.
Publicado: (2012) -
TRPM8 on mucosal sensory nerves regulates colitogenic responses by
innate immune cells via CGRP
por: de Jong, Petrus R., et al.
Publicado: (2014) -
Pharmacological Blockade of TRPM8 Ion Channels Alters Cold and Cold Pain Responses in Mice
por: Knowlton, Wendy M., et al.
Publicado: (2011) -
Sensory discrimination between innocuous and noxious cold by TRPM8-expressing DRG neurons of rats
por: Sarria, Ignacio, et al.
Publicado: (2012) -
Involvement of TRPM2 and TRPM8 in temperature-dependent masking behavior
por: Ota, Wataru, et al.
Publicado: (2019)