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Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation

INTRODUCTION: Systemic lupus erythematosus (SLE) is an autoimmune disease associated with a break in self-tolerance reflected by a production of antinuclear autoantibodies. Since autoantibody production can be activated via nucleic acid Toll-like receptor 9 (TLR9), the respective pathway has been im...

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Detalles Bibliográficos
Autores principales: Sieber, Julia, Daridon, Capucine, Fleischer, Sarah J, Fleischer, Vanessa, Hiepe, Falk, Alexander, Tobias, Heine, Guido, Burmester, Gerd R, Fillatreau, Simon, Dörner, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247768/
https://www.ncbi.nlm.nih.gov/pubmed/25385499
http://dx.doi.org/10.1186/s13075-014-0477-1