Cargando…

Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation

INTRODUCTION: Systemic lupus erythematosus (SLE) is an autoimmune disease associated with a break in self-tolerance reflected by a production of antinuclear autoantibodies. Since autoantibody production can be activated via nucleic acid Toll-like receptor 9 (TLR9), the respective pathway has been im...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sieber, Julia, Daridon, Capucine, Fleischer, Sarah J, Fleischer, Vanessa, Hiepe, Falk, Alexander, Tobias, Heine, Guido, Burmester, Gerd R, Fillatreau, Simon, Dörner, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247768/ https://www.ncbi.nlm.nih.gov/pubmed/25385499 http://dx.doi.org/10.1186/s13075-014-0477-1

Ejemplares similares

Epratuzumab inhibits the production of the proinflammatory cytokines IL-6 and TNF-α, but not the regulatory cytokine IL-10, by B cells from healthy donors and SLE patients
por: Fleischer, Vanessa, et al.
Publicado: (2015)

Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis
por: Smith, Michael F, et al.
Publicado: (2009)

Toll-like receptor signalling in B cells during systemic lupus erythematosus
por: Fillatreau, Simon, et al.
Publicado: (2020)

The cytokine memory of SmD1(83-119)-autoantigen-specific Th cells of systemic lupus erythematosus patients
por: Langer, S, et al.
Publicado: (2005)

Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus
por: Daridon, Capucine, et al.
Publicado: (2010)

Therapeutic inhibition of proteasomes in systemic lupus erythematosus
por: Hiepe, Falk, et al.
Publicado: (2011)

Developments in lupus 2006
por: Hansen, Arne, et al.
Publicado: (2007)

SIGLEC1 is a biomarker of disease activity and indicates extraglandular manifestation in primary Sjögren's syndrome
por: Rose, Thomas, et al.
Publicado: (2016)

Differential expression of chemokine receptors on peripheral blood B cells from patients with rheumatoid arthritis and systemic lupus erythematosus
por: Henneken, Maren, et al.
Publicado: (2005)

Correlation between TLR9 Expression and Cytokine Secretion in the Clinical Diagnosis of Systemic Lupus Erythematosus
por: Rao, Hui, et al.
Publicado: (2015)

Analysis of B-cell subpopulations in systemic lupus erythematosus
por: Dorner, T, et al.
Publicado: (2003)

Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus
por: Dörner, Thomas, et al.
Publicado: (2006)

Diagnostic value and clinical laboratory associations of antibodies against recombinant ribosomal P0, P1 and P2 proteins and their native heterocomplex in a Caucasian cohort with systemic lupus erythematosus
por: Barkhudarova, Fidan, et al.
Publicado: (2011)

Severe Maternal Morbidity Associated with Systemic Lupus Erythematosus Flare in the Second Trimester of Pregnancy
por: Blitz, Matthew J., et al.
Publicado: (2018)

Correction: Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus
por: Dörner, Thomas, et al.
Publicado: (2008)

A Narrative Literature Review Comparing the Key Features of Musculoskeletal Involvement in Rheumatoid Arthritis and Systemic Lupus Erythematosus
por: Dörner, Thomas, et al.
Publicado: (2022)

Anti-dsDNA-NcX ELISA: dsDNA-loaded nucleosomes improve diagnosis and monitoring of disease activity in systemic lupus erythematosus
por: Biesen, Robert, et al.
Publicado: (2011)

The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus
por: Alexander, Tobias, et al.
Publicado: (2015)

Antibodies against type I IFN: The bad guys self-restrain in systemic lupus erythematosus
por: Fillatreau, Simon
Publicado: (2023)

The anti-CD74 humanized monoclonal antibody, milatuzumab, which targets the invariant chain of MHC II complexes, alters B-cell proliferation, migration, and adhesion molecule expression
por: Frölich, Daniela, et al.
Publicado: (2012)

Cytokines in Systemic Lupus Erythematosus
por: Poole, Brian D., et al.
Publicado: (2010)

Association of TLR7 and TLR9 genes polymorphisms in Egyptian patients with systemic lupus erythematosus
por: Azab, Marwa M., et al.
Publicado: (2022)

Kitasato symposium 2011: translational prospects for cytokines
por: Burmester, Gerd R, et al.
Publicado: (2011)

Kitasato symposium 2010: new prospects for cytokines
por: Burmester, Gerd R, et al.
Publicado: (2010)

Cytokine Networks in Systemic Lupus Erythematosus
por: Lee, Hooi-Ming, et al.
Publicado: (2010)

Cytokines in Systemic Lupus Erythematosus 2011
por: Poole, Brian D., et al.
Publicado: (2012)

Inflammatory Cytokines in Systemic Lupus Erythematosus
por: Ohl, Kim, et al.
Publicado: (2011)

Cytokine disturbances in systemic lupus erythematosus
por: Jacob, Noam, et al.
Publicado: (2011)

Kitasato Symposium 2009: New Prospects for Cytokine Inhibition
por: Burmester, Gerd R, et al.
Publicado: (2009)

Pathogenic memory plasma cells in autoimmunity
por: Chang, Hyun-Dong, et al.
Publicado: (2019)

TLR-9, but not TLR-2, TLR-3 and TLR-4, is upregulated on peripheral blood mononuclear cells of patients with active systemic lupus erythematosus
por: Papadimitraki, ED, et al.
Publicado: (2005)

Characteristics of cardiovascular autonomic dysfunction and association with quality of life in patients with systemic lupus erythematosus
por: Zinglersen, Amanda Hempel, et al.
Publicado: (2021)

Cytokines in systemic lupus erythematosus, London, UK
por: Rahman, Anisur
Publicado: (2003)

Anti-Cytokine Autoantibodies in Systemic Lupus Erythematosus
por: Howe, Hwee Siew, et al.
Publicado: (2019)

Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus
por: Ma, Kongyang, et al.
Publicado: (2015)

Regulatory T-Cell-Associated Cytokines in Systemic Lupus Erythematosus
por: Okamoto, Akiko, et al.
Publicado: (2011)

Cytokines and Chemokines in Neuropsychiatric Syndromes of Systemic Lupus Erythematosus
por: Okamoto, Hiroshi, et al.
Publicado: (2010)

Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus
por: Sinicato, Nailú Angélica, et al.
Publicado: (2014)

Cytokine and autoantibody clusters interaction in systemic lupus erythematosus
por: Pacheco, Yovana, et al.
Publicado: (2017)

Cytokine imbalance in NZB/W mice is associated with autoantibody levels and nephritis
por: Enghard, P, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_s32p1pe88jkmik799vkhn0qiv8