Cargando…

Hydrocarbon molar water solubility predicts NMDA vs. GABA(A) receptor modulation

BACKGROUND: Many anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABA(A)) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar water solubility of a hydrocarbon could b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brosnan, Robert J, Pham, Trung L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247779/ https://www.ncbi.nlm.nih.gov/pubmed/25410726 http://dx.doi.org/10.1186/2050-6511-15-62

Ejemplares similares

Anesthetic-sensitive ion channel modulation is associated with a molar water solubility cut-off
por: Brosnan, Robert J., et al.
Publicado: (2018)

Increased NMDA receptor inhibition at an increased Sevoflurane MAC
por: Brosnan, Robert J, et al.
Publicado: (2012)

Differential Modulation of GABA(A) and NMDA Receptors by an α7-nicotinic Acetylcholine Receptor Agonist in Chronic Glaucoma
por: Zhou, Xujiao, et al.
Publicado: (2017)

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABA(A) receptor mediated currents
por: Lee, Henry H.C., et al.
Publicado: (2011)

A Role for Adenosine A1 Receptors in GABA and NMDA-Receptor Mediated Modulation of Dopamine Release: Studies Using Fast Cyclic Voltammetry
por: O′Connor, John J., et al.
Publicado: (2008)

Qualitatively different scenarios for co-activation of NMDA, AMPA and GABA receptor currents on dopaminergic neuron
por: Zakharov, Denis, et al.
Publicado: (2015)

Modulation of NMDA Receptor Activity in Fibromyalgia
por: Littlejohn, Geoffrey, et al.
Publicado: (2017)

Associations between PTSD-Related extinction retention deficits in women and plasma steroids that modulate brain GABA(A) and NMDA receptor activity
por: Pineles, Suzanne L., et al.
Publicado: (2020)

Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia
por: Holubova, Kristina, et al.
Publicado: (2021)

Effects of NMDA and GABA-A Receptor Antagonism on Auditory Steady-State Synchronization in Awake Behaving Rats
por: Sullivan, Elyse M., et al.
Publicado: (2015)

GABA(A) and NMDA receptor density alterations and their behavioral correlates in the gestational methylazoxymethanol acetate model for schizophrenia
por: Kiemes, Amanda, et al.
Publicado: (2021)

Differential Regulation of GABA(B) Receptor Trafficking by Different Modes of N-methyl-d-aspartate (NMDA) Receptor Signaling
por: Kantamneni, Sriharsha, et al.
Publicado: (2014)

Impulsive behaviour induced by both NMDA receptor antagonism and GABA(A) receptor activation in rat ventromedial prefrontal cortex
por: Murphy, Emily R., et al.
Publicado: (2011)

Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABA(A) receptors
por: Schulz, Jan M., et al.
Publicado: (2018)

NMDA Receptor Modulators in the Treatment of Drug Addiction
por: Tomek, Seven E., et al.
Publicado: (2013)

Structure, function, and allosteric modulation of NMDA receptors
por: Hansen, Kasper B., et al.
Publicado: (2018)

Spider Neurotoxins as Modulators of NMDA Receptor Signaling
por: Pałasz, Artur, et al.
Publicado: (2021)

GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics
por: Bhandage, Amol K., et al.
Publicado: (2014)

Proceedings: The metabolic formation of water-soluble derivatives from dihydrodiols of polycyclic hydrocarbons.
por: Keysell, G. R., et al.
Publicado: (1975)

Biphasic Modulation of NMDA Receptor Function by Metabotropic Glutamate Receptors
por: O'Neill, Nathanael, et al.
Publicado: (2018)

NMDA receptor modulation of glutamate release in activated neutrophils
por: del Arroyo, Ana Gutierrez, et al.
Publicado: (2019)

GABA and the GABA(A) Receptor
por: Mihic, S. John, et al.
Publicado: (1997)

GABA(A) Receptor- and Non-NMDA Glutamate Receptor-Mediated Actions of Korean Red Ginseng Extract on the Gonadotropin Releasing Hormone Neurons
por: Cho, Dong Hyu, et al.
Publicado: (2012)

Allosteric Modulation of αβδ GABA(A) Receptors
por: Feng, Hua-Jun
Publicado: (2010)

NMDA receptors control development of somatosensory callosal axonal projections
por: Zhou, Jing, et al.
Publicado: (2021)

Soluble amyloid-β precursor peptide does not regulate GABA(B) receptor activity
por: Rem, Pascal Dominic, et al.
Publicado: (2023)

The Anticonvulsant Activity of a Flavonoid-Rich Extract from Orange Juice Involves both NMDA and GABA-Benzodiazepine Receptor Complexes
por: Citraro, Rita, et al.
Publicado: (2016)

Brain blood vessel autoantibodies in patients with NMDA and GABA(A) receptor encephalitis: identification of unconventional Myosin-X as target antigen
por: Li, Lucie Y., et al.
Publicado: (2023)

Scopolamine Administration Modulates Muscarinic, Nicotinic and NMDA Receptor Systems
por: Falsafi, Soheil Keihan, et al.
Publicado: (2012)

Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators
por: Yao, Lulu, et al.
Publicado: (2017)

GPR40 modulates epileptic seizure and NMDA receptor function
por: Yang, Yong, et al.
Publicado: (2018)

NMDA receptor modulation and severe acute respiratory syndrome treatment
por: Costa, Blaise M.
Publicado: (2021)

Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives
por: Ritter, Nadine, et al.
Publicado: (2023)

Allosteric modulation of GABA(A) receptors by extracellular ATP
por: Liu, Jun, et al.
Publicado: (2014)

Metabolic Products of Linalool and Modulation of GABA(A) Receptors
por: Milanos, Sinem, et al.
Publicado: (2017)

KCTD12 modulation of GABA(B) receptor function
por: Li, Melody, et al.
Publicado: (2017)

Novel pyrazolothienopyridinones as potential GABA(A) receptor modulators
por: Vega Alanis, Blanca Angelica, et al.
Publicado: (2023)

The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration
por: Perry, Alistair, et al.
Publicado: (2022)

NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies
por: Steinke, Stephan, et al.
Publicado: (2023)

Hydrocarbon-soluble, hexaanionic fulleride complexes of magnesium
por: Lawrence, Samuel R., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1le2473o997c50a8h30ls79kut