Targeting the INCENP IN-box–Aurora B interaction to inhibit CPC activity in vivo

The chromosome passenger complex (CPC) is an essential regulator of mitosis and cytokinesis. The CPC consists of Aurora B kinase, inner centromere protein (INCENP), and the targeting subunits survivin and borealin/Dasra B. INCENP is a scaffolding subunit for the CPC and activates Aurora B via its co...

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Detalles Bibliográficos
Autores principales: Gohard, Florence H., St-Cyr, Daniel J., Tyers, Mike, Earnshaw, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248066/
https://www.ncbi.nlm.nih.gov/pubmed/25392451
http://dx.doi.org/10.1098/rsob.140163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248066/
https://www.ncbi.nlm.nih.gov/pubmed/25392451
http://dx.doi.org/10.1098/rsob.140163

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