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Targeting the INCENP IN-box–Aurora B interaction to inhibit CPC activity in vivo

The chromosome passenger complex (CPC) is an essential regulator of mitosis and cytokinesis. The CPC consists of Aurora B kinase, inner centromere protein (INCENP), and the targeting subunits survivin and borealin/Dasra B. INCENP is a scaffolding subunit for the CPC and activates Aurora B via its co...

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Detalles Bibliográficos
Autores principales:	Gohard, Florence H., St-Cyr, Daniel J., Tyers, Mike, Earnshaw, William C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248066/ https://www.ncbi.nlm.nih.gov/pubmed/25392451 http://dx.doi.org/10.1098/rsob.140163

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