Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate

Alternative splicing modulates expression of most human genes. The kinetic model of cotranscriptional splicing suggests that slow elongation expands and that fast elongation compresses the “window of opportunity” for recognition of upstream splice sites, thereby increasing or decreasing inclusion of...

Descripción completa

Detalles Bibliográficos
Autores principales: Fong, Nova, Kim, Hyunmin, Zhou, Yu, Ji, Xiong, Qiu, Jinsong, Saldi, Tassa, Diener, Katrina, Jones, Ken, Fu, Xiang-Dong, Bentley, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248296/
https://www.ncbi.nlm.nih.gov/pubmed/25452276
http://dx.doi.org/10.1101/gad.252106.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248296/
https://www.ncbi.nlm.nih.gov/pubmed/25452276
http://dx.doi.org/10.1101/gad.252106.114

Ejemplares similares