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Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate
Alternative splicing modulates expression of most human genes. The kinetic model of cotranscriptional splicing suggests that slow elongation expands and that fast elongation compresses the “window of opportunity” for recognition of upstream splice sites, thereby increasing or decreasing inclusion of...
Autores principales: | Fong, Nova, Kim, Hyunmin, Zhou, Yu, Ji, Xiong, Qiu, Jinsong, Saldi, Tassa, Diener, Katrina, Jones, Ken, Fu, Xiang-Dong, Bentley, David L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248296/ https://www.ncbi.nlm.nih.gov/pubmed/25452276 http://dx.doi.org/10.1101/gad.252106.114 |
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