Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

Promiscuous gene expression (PGE) by thymic epithelial cells (TEC) is essential for generating a diverse T cell antigen receptor repertoire tolerant to self-antigens, and thus for avoiding autoimmunity. Nevertheless, the extent and nature of this unusual expression program within TEC populations and...

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Detalles Bibliográficos
Autores principales: Sansom, Stephen N., Shikama-Dorn, Noriko, Zhanybekova, Saule, Nusspaumer, Gretel, Macaulay, Iain C., Deadman, Mary E., Heger, Andreas, Ponting, Chris P., Holländer, Georg A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248310/
https://www.ncbi.nlm.nih.gov/pubmed/25224068
http://dx.doi.org/10.1101/gr.171645.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248310/
https://www.ncbi.nlm.nih.gov/pubmed/25224068
http://dx.doi.org/10.1101/gr.171645.113

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