Secreted clusterin (sCLU) regulates cell proliferation and chemosensitivity to cisplatin by modulating ERK1/2 signals in human osteosarcoma cells

BACKGROUND: Several studies have shown that secreted clusterin (sCLU) up-regulation in multi-drug resistant osteosarcoma (OS) cells relates to enhanced drug resistance. Furthermore, sCLU silencing directed against sCLU induces significant reduction of cellular growth and sensitizes OS cells to chemo...

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Detalles Bibliográficos
Autores principales: Huang, Hai, Wang, Linna, Li, Mingyu, Wang, Xiaohui, Zhang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249734/
https://www.ncbi.nlm.nih.gov/pubmed/25106434
http://dx.doi.org/10.1186/1477-7819-12-255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249734/
https://www.ncbi.nlm.nih.gov/pubmed/25106434
http://dx.doi.org/10.1186/1477-7819-12-255

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