Cargando…

Secreted clusterin (sCLU) regulates cell proliferation and chemosensitivity to cisplatin by modulating ERK1/2 signals in human osteosarcoma cells

BACKGROUND: Several studies have shown that secreted clusterin (sCLU) up-regulation in multi-drug resistant osteosarcoma (OS) cells relates to enhanced drug resistance. Furthermore, sCLU silencing directed against sCLU induces significant reduction of cellular growth and sensitizes OS cells to chemo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Hai, Wang, Linna, Li, Mingyu, Wang, Xiaohui, Zhang, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249734/ https://www.ncbi.nlm.nih.gov/pubmed/25106434 http://dx.doi.org/10.1186/1477-7819-12-255

Ejemplares similares

sCLU regulates cisplatin chemosensitivity of lung cancer cells in vivo
por: Ma, Guoliang, et al.
Publicado: (2015)

sCLU as prognostic biomarker and therapeutic target in osteosarcoma
por: Ma, Jinfeng, et al.
Publicado: (2019)

ATM Regulates Insulin-Like Growth Factor 1-Secretory Clusterin (IGF-1-sCLU) Expression that Protects Cells against Senescence
por: Luo, Xiuquan, et al.
Publicado: (2014)

Overexpression of secretory clusterin (sCLU) induces chemotherapy resistance in human gastric cancer cells by targeting miR-195-5p
por: Mu, Lihua, et al.
Publicado: (2020)

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations
por: Bettens, Karolien, et al.
Publicado: (2015)

Preliminary Study on Clusterin Protein (sCLU) Expression in PC-12 Cells Overexpressing Wild-Type and Mutated (Swedish) AβPP genes Affected by Non-Steroid Isoprenoids and Water-Soluble Cholesterol
por: Pająk, Beata, et al.
Publicado: (2019)

A pan-cancer analysis reveals role of clusterin (CLU) in carcinogenesis and prognosis of human tumors
por: Fu, Yizhe, et al.
Publicado: (2023)

RNAi-mediated knockdown of ERK1/2 inhibits cell proliferation and invasion and increases chemosensitivity to cisplatin in human osteosarcoma U2-OS cells in vitro
por: SI, HAIPENG, et al.
Publicado: (2011)

Plasma Clusterin and the CLU Gene rs11136000 Variant Are Associated with Mild Cognitive Impairment in Type 2 Diabetic Patients
por: Cai, Rongrong, et al.
Publicado: (2016)

Hsa_circ_0063804 enhances ovarian cancer cells proliferation and resistance to cisplatin by targeting miR-1276/CLU axis
por: You, Jun, et al.
Publicado: (2022)

Low dose IR-induced IGF-1-sCLU expression: a p53-repressed expression cascade that interferes with TGFβ1 signaling to confer a pro-survival bystander effect
por: Klokov, Dmitry, et al.
Publicado: (2012)

CluMan
por: Lopienski, Sebastian
Publicado: (2008)

miRNA-378 reverses chemoresistance to cisplatin in lung adenocarcinoma cells by targeting secreted clusterin
por: Chen, Xuesong, et al.
Publicado: (2016)

Effects of NOB1 on the pathogenesis of osteosarcoma and its expression on the chemosensitivity to cisplatin
por: Luo, Leiming, et al.
Publicado: (2018)

Lentivirus-mediated RNA interference of clusterin enhances the chemosensitivity of EJ bladder cancer cells to epirubicin in vitro
por: Lu, Jian, et al.
Publicado: (2021)

Cell fate determination in cisplatin resistance and chemosensitization
por: Luong, Khanh V., et al.
Publicado: (2016)

Cordycepin augments the chemosensitivity of osteosarcoma to cisplatin by activating AMPK and suppressing the AKT signaling pathway
por: Li, Hong-Bo, et al.
Publicado: (2021)

CluMan - Cluster management toolsuit
por: Siket, M, et al.
Publicado: (2010)

MiR-200c regulates tumor growth and chemosensitivity to cisplatin in osteosarcoma by targeting AKT2
por: Liu, Yang, et al.
Publicado: (2017)

Enhancement of conformational B-cell epitope prediction using CluSMOTE
por: Solihah, Binti, et al.
Publicado: (2020)

Knockdown of clusterin sensitizes pancreatic cancer cells to gemcitabine chemotherapy by ERK1/2 inactivation
por: Tang, Yong, et al.
Publicado: (2012)

CLU: A new algorithm for EST clustering
por: Ptitsyn, Andrey, et al.
Publicado: (2005)

CLU blocks HDACI-mediated killing of neuroblastoma
por: Subramanian, Chitra, et al.
Publicado: (2010)

Overexpression of Ulk2 inhibits proliferation and enhances chemosensitivity to cisplatin in non-small cell lung cancer
por: Cheng, Hong, et al.
Publicado: (2019)

MicroRNA-141 and its associated gene FUS modulate proliferation, migration and cisplatin chemosensitivity in neuroblastoma cell lines
por: WANG, ZIRAN, et al.
Publicado: (2016)

Dacomitinib improves chemosensitivity of cisplatin-resistant human ovarian cancer cells
por: Xu, Lei, et al.
Publicado: (2021)

Clusterin silencing inhibits proliferation and reduces invasion in human laryngeal squamous carcinoma cells
por: Wang, Qianjin, et al.
Publicado: (2014)

RNAi-mediated silencing of CD147 inhibits tumor cell proliferation, invasion and increases chemosensitivity to cisplatin in SGC7901 cells in vitro
por: Wang, Bo, et al.
Publicado: (2010)

Knockdown of STMN1 enhances osteosarcoma cell chemosensitivity through inhibition of autophagy
por: Wang, Zili, et al.
Publicado: (2017)

Correction: Knockdown of clusterin sensitizes pancreatic cancer cells to gemcitabine chemotherapy by ERK1/2 inactivation
por: Tang, Yong, et al.
Publicado: (2013)

Clusterin Protects Lipotoxicity-Induced Apoptosis via Upregulation of Autophagy in Insulin-Secreting Cells
por: Hong, Seok-Woo, et al.
Publicado: (2020)

Astragali radix total flavonoid synergizes cisplatin to inhibit proliferation and enhances the chemosensitivity of laryngeal squamous cell carcinoma
por: Cui, Jiajia, et al.
Publicado: (2019)

Genetic Variability in CLU and Its Association with Alzheimer's Disease
por: Guerreiro, Rita J., et al.
Publicado: (2010)

CLU Polymorphisms in Patients with Pseudoexfoliation Syndrome in Polish Population
por: Lesiewska, Hanna, et al.
Publicado: (2019)

Alternative Splicing Regulation of an Alzheimer’s Risk Variant in CLU
por: Han, Seonggyun, et al.
Publicado: (2020)

Short hairpin RNA targeting Twist1 suppresses cell proliferation and improves chemosensitivity to cisplatin in HeLa human cervical cancer cells
por: ZHU, KEXIU, et al.
Publicado: (2012)

MicroRNA-21 Increases Proliferation and Cisplatin Sensitivity of Osteosarcoma-Derived Cells
por: Vanas, Vanita, et al.
Publicado: (2016)

Curcumin Derivative C086 Combined with Cisplatin Inhibits Proliferation of Osteosarcoma Cells
por: Jiang, Xi, et al.
Publicado: (2020)

Naa10p Enhances Chemosensitivity to Cisplatin in Oral Squamous Cell Carcinoma Cells
por: Sun, Lichun, et al.
Publicado: (2021)

Molecular Mechanism of Gas Anesthetics on the Invasion, Metastasis, and Chemosensitivity of Osteosarcoma Cells
por: Zhao, Qian, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1elna4r8875j9abpc0vpdqb50l