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Expanding metabolic engineering algorithms using feasible space and shadow price constraint modules

While numerous computational methods have been developed that use genome-scale models to propose mutants for the purpose of metabolic engineering, they generally compare mutants based on a single criteria (e.g., production rate at a mutant׳s maximum growth rate). As such, these approaches remain lim...

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Detalles Bibliográficos
Autores principales: Tervo, Christopher J., Reed, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249821/
https://www.ncbi.nlm.nih.gov/pubmed/25478320
http://dx.doi.org/10.1016/j.meteno.2014.06.001