Adamantyl Analogues of Paracetamol as Potent Analgesic Drugs via Inhibition of TRPA1

Paracetamol also known as acetaminophen, is a widely used analgesic and antipyretic agent. We report the synthesis and biological evaluation of adamantyl analogues of paracetamol with important analgesic properties. The mechanism of nociception of compound 6a/b, an analog of paracetamol, is not exer...

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Detalles Bibliográficos
Autores principales: Fresno, Nieves, Pérez-Fernández, Ruth, Goicoechea, Carlos, Alkorta, Ibon, Fernández-Carvajal, Asia, de la Torre-Martínez, Roberto, Quirce, Susana, Ferrer-Montiel, Antonio, Martín, M. Isabel, Goya, Pilar, Elguero, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249970/
https://www.ncbi.nlm.nih.gov/pubmed/25438056
http://dx.doi.org/10.1371/journal.pone.0113841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249970/
https://www.ncbi.nlm.nih.gov/pubmed/25438056
http://dx.doi.org/10.1371/journal.pone.0113841

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