Cargando…

Interface Matters: The Stiffness Route to Stability of a Thermophilic Tetrameric Malate Dehydrogenase

In this work we investigate by computational means the behavior of two orthologous bacterial proteins, a mesophilic and a thermophilic tetrameric malate dehydrogenase (MalDH), at different temperatures. Namely, we quantify how protein mechanical rigidity at different length- and time-scales correlat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kalimeri, Maria, Girard, Eric, Madern, Dominique, Sterpone, Fabio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250060/ https://www.ncbi.nlm.nih.gov/pubmed/25437494 http://dx.doi.org/10.1371/journal.pone.0113895

Ejemplares similares

Protein Conformational Space at the Edge of Allostery: Turning a Nonallosteric Malate Dehydrogenase into an “Allosterized” Enzyme Using Evolution-Guided Punctual Mutations
por: Iorio, Antonio, et al.
Publicado: (2022)

Resurrection of Ancestral Malate Dehydrogenases Reveals the Evolutionary History of Halobacterial Proteins: Deciphering Gene Trajectories and Changes in Biochemical Properties
por: Blanquart, Samuel, et al.
Publicado: (2021)

Thermal activation of ‘allosteric-like’ large-scale motions in a eukaryotic Lactate Dehydrogenase
por: Katava, Marina, et al.
Publicado: (2017)

Deciphering Evolutionary Trajectories of Lactate Dehydrogenases Provides New Insights into Allostery
por: Robin, Adeline Y, et al.
Publicado: (2023)

Crystal Structures and Molecular Dynamics Simulations of Thermophilic Malate Dehydrogenase Reveal Critical Loop Motion for Co-Substrate Binding
por: Hung, Chih-Hung, et al.
Publicado: (2013)

Tetramerization Reinforces the Dimer Interface of MnSOD
por: Sheng, Yuewei, et al.
Publicado: (2013)

Structure and Kinetic Stability of the p63 Tetramerization Domain
por: Natan, Eviatar, et al.
Publicado: (2012)

Structural Insights into the Tetrameric State of Aspartate-β-semialdehyde Dehydrogenases from Fungal Species
por: Li, Qinqin, et al.
Publicado: (2016)

Discovery of a novel lactate dehydrogenase tetramerization domain using epitope mapping and peptides
por: Thabault, Léopold, et al.
Publicado: (2021)

Oligomeric interfaces as a tool in drug discovery: Specific interference with activity of malate dehydrogenase of Plasmodium falciparum in vitro
por: Lunev, Sergey, et al.
Publicado: (2018)

Structural Characterization of the Human Cytosolic Malate Dehydrogenase I
por: McCue, William M., et al.
Publicado: (2021)

GapR binds DNA through dynamic opening of its tetrameric interface
por: Huang, Qian, et al.
Publicado: (2020)

Malic Enzyme, not Malate Dehydrogenase, Mainly Oxidizes Malate That Originates from the Tricarboxylic Acid Cycle in Cyanobacteria
por: Katayama, Noriaki, et al.
Publicado: (2022)

An experimental point of view on hydration/solvation in halophilic proteins
por: Talon, Romain, et al.
Publicado: (2014)

Multiple strategies to prevent oxidative stress in Arabidopsis plants lacking the malate valve enzyme NADP-malate dehydrogenase
por: Hebbelmann, Inga, et al.
Publicado: (2012)

Malate metabolism mediated by the cytoplasmic malate dehydrogenase gene MdcyMDH affects sucrose synthesis in apple fruit
por: Zhang, Lihua, et al.
Publicado: (2022)

Plasmodium Parasite Malate-Quinone Oxidoreductase Functionally Complements a Yeast Deletion Mutant of Mitochondrial Malate Dehydrogenase
por: Ito, Takeshi, et al.
Publicado: (2023)

Alternative Splicing Regulates Targeting of Malate Dehydrogenase in Yarrowia lipolytica
por: Kabran, Philomène, et al.
Publicado: (2012)

Characterization of the Role of the Malate Dehydrogenases to Lung Tumor Cell Survival
por: Zhang, Boxi, et al.
Publicado: (2017)

Gradual neofunctionalization in the convergent evolution of trichomonad lactate and malate dehydrogenases
por: Steindel, Phillip A., et al.
Publicado: (2016)

Identification and Characterization of Malate Dehydrogenases in Tomato (Solanum lycopersicum L.)
por: Imran, Muhammad, et al.
Publicado: (2022)

Structural Insight into the Tetramerization of an Iterative Ketoreductase SiaM through Aromatic Residues in the Interfaces
por: Wang, Hua, et al.
Publicado: (2014)

Polar Interactions at the Dimer–Dimer Interface of Methionine Adenosyltransferase MAT I Control Tetramerization
por: Sánchez-Pérez, Gabino Francisco, et al.
Publicado: (2021)

Pre-existing antibodies directed against a tetramerizing domain enhance the immune response against artificially stabilized soluble tetrameric influenza neuraminidase
por: Catani, João Paulo Portela, et al.
Publicado: (2022)

Diverse allosteric and catalytic functions of tetrameric d-lactate dehydrogenases from three Gram-negative bacteria
por: Furukawa, Nayuta, et al.
Publicado: (2014)

An (R)-Selective Transaminase From Thermomyces stellatus: Stabilizing the Tetrameric Form
por: Heckmann, Christian M., et al.
Publicado: (2020)

Di- and Tetrameric Molybdenum Sulfide Clusters Activate and Stabilize Dihydrogen as Hydrides
por: Khare, Rachit, et al.
Publicado: (2022)

Cryo-EM structure of a tetrameric photosystem I from Chroococcidiopsis TS-821, a thermophilic, unicellular, non-heterocyst-forming cyanobacterium
por: Semchonok, Dmitry A., et al.
Publicado: (2021)

Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer
por: Hanse, Eric A, et al.
Publicado: (2017)

The cytoplasmic malate dehydrogenase in neoplastic tissues; presence of a novel isoenzyme?
por: Grisham, M. B., et al.
Publicado: (1983)

Comparative Genome-Wide Analysis of the Malate Dehydrogenase Gene Families in Cotton
por: Imran, Muhammad, et al.
Publicado: (2016)

Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase
por: Ahn, Jung Ho, et al.
Publicado: (2020)

Evaluation on the responses of succinate dehydrogenase, isocitrate dehydrogenase, malate dehydrogenase and glucose-6-phosphate dehydrogenase to acid shock generated acid tolerance in Escherichia coli
por: Jain, Pradeep Kumar, et al.
Publicado: (2013)

Quality Matters: Extension of Clusters of Residues with Good Hydrophobic Contacts Stabilize (Hyper)Thermophilic Proteins
por: Rathi, Prakash Chandra, et al.
Publicado: (2014)

Human lactate dehydrogenase A undergoes allosteric transitions under pH conditions inducing the dissociation of the tetrameric enzyme
por: Pasti, Alberto Pietro, et al.
Publicado: (2022)

Automatic determination of malate dehydrogenase activity with a flow-injection multidetection system
por: Fernández-Romero, J. M., et al.
Publicado: (1990)

Effects of Al(III) and Nano-Al(13) Species on Malate Dehydrogenase Activity
por: Yang, Xiaodi, et al.
Publicado: (2011)

The functional readthrough extension of malate dehydrogenase reveals a modification of the genetic code
por: Hofhuis, Julia, et al.
Publicado: (2016)

Identification and characterization of cytosolic malate dehydrogenase from the liver fluke Fasciola gigantica
por: Chetri, Purna Bahadur, et al.
Publicado: (2020)

Increasing access for biochemistry research in undergraduate education: The malate dehydrogenase CURE community
por: Provost, Joseph J.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_r0hijkj381j4va5icd2r9ljl0j