Reversible Blockade of Complex I or Inhibition of PKCβ Reduces Activation and Mitochondria Translocation of p66(Shc) to Preserve Cardiac Function after Ischemia

AIM: Excess mitochondrial reactive oxygen species (mROS) play a vital role in cardiac ischemia reperfusion (IR) injury. P66(Shc), a splice variant of the ShcA adaptor protein family, enhances mROS production by oxidizing reduced cytochrome c to yield H(2)O(2). Ablation of p66(Shc) protects against I...

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Detalles Bibliográficos
Autores principales: Yang, Meiying, Stowe, David F., Udoh, Kenechukwu B., Heisner, James S., Camara, Amadou K. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250075/
https://www.ncbi.nlm.nih.gov/pubmed/25436907
http://dx.doi.org/10.1371/journal.pone.0113534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250075/
https://www.ncbi.nlm.nih.gov/pubmed/25436907
http://dx.doi.org/10.1371/journal.pone.0113534

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