PRMT5 Protects Genomic Integrity during Global DNA Demethylation in Primordial Germ Cells and Preimplantation Embryos

Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming, which includes comprehensive DNA demethylation. We found that PRMT5, an arginine methyltransferase, translocates from the cytoplasm to the nucleus during this process. Here we show that conditional loss of PRM...

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Detalles Bibliográficos
Autores principales: Kim, Shinseog, Günesdogan, Ufuk, Zylicz, Jan J., Hackett, Jamie A., Cougot, Delphine, Bao, Siqin, Lee, Caroline, Dietmann, Sabine, Allen, George E., Sengupta, Roopsha, Surani, M. Azim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250265/
https://www.ncbi.nlm.nih.gov/pubmed/25457166
http://dx.doi.org/10.1016/j.molcel.2014.10.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250265/
https://www.ncbi.nlm.nih.gov/pubmed/25457166
http://dx.doi.org/10.1016/j.molcel.2014.10.003

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