The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data

PURPOSE: To develop and evaluate a tool for the qualitative prediction of human oral bioavailability (F(human)) from animal oral bioavailability (F(animal)) data employing ROC analysis and to identify the optimal thresholds for such predictions. METHODS: A dataset of 184 compounds with known F(human...

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Detalles Bibliográficos
Autores principales: Olivares-Morales, Andrés, Hatley, Oliver J. D., Turner, David, Galetin, Aleksandra, Aarons, Leon, Rostami-Hodjegan, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250569/
https://www.ncbi.nlm.nih.gov/pubmed/24072264
http://dx.doi.org/10.1007/s11095-013-1193-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250569/
https://www.ncbi.nlm.nih.gov/pubmed/24072264
http://dx.doi.org/10.1007/s11095-013-1193-2

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