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The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data
PURPOSE: To develop and evaluate a tool for the qualitative prediction of human oral bioavailability (F(human)) from animal oral bioavailability (F(animal)) data employing ROC analysis and to identify the optimal thresholds for such predictions. METHODS: A dataset of 184 compounds with known F(human...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250569/ https://www.ncbi.nlm.nih.gov/pubmed/24072264 http://dx.doi.org/10.1007/s11095-013-1193-2 |