Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data

BACKGROUND: The transcription factor 7-like 2 (TCF7L2) locus is strongly implicated in the pathogenesis of type 2 diabetes (T2D). We previously mapped the genomic regions bound by TCF7L2 using ChIP (chromatin immunoprecipitation)-seq in the colorectal carcinoma cell line, HCT116, revealing an unexpe...

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Detalles Bibliográficos
Autores principales: Johnson, Matthew E, Zhao, Jianhua, Schug, Jonathan, Deliard, Sandra, Xia, Qianghua, Guy, Vanessa C, Sainz, Jesus, Kaestner, Klaus H, Wells, Andrew D, Grant, Struan F A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2014
Materias:
Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250976/
https://www.ncbi.nlm.nih.gov/pubmed/25469308
http://dx.doi.org/10.1136/bmjdrc-2014-000052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250976/
https://www.ncbi.nlm.nih.gov/pubmed/25469308
http://dx.doi.org/10.1136/bmjdrc-2014-000052

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