Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin

The potential alterations to structure and associations with thin filament proteins caused by the dilated cardiomyopathy (DCM) associated tropomyosin (Tm) mutants E40K and E54K, and the hypertrophic cardiomyopathy (HCM) associated Tm mutants E62Q and L185R, were investigated. In order to ascertain w...

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Detalles Bibliográficos
Autores principales: Chang, Audrey N., Greenfield, Norma J., Singh, Abhishek, Potter, James D., Pinto, Jose R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251307/
https://www.ncbi.nlm.nih.gov/pubmed/25520664
http://dx.doi.org/10.3389/fphys.2014.00460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251307/
https://www.ncbi.nlm.nih.gov/pubmed/25520664
http://dx.doi.org/10.3389/fphys.2014.00460

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