Differentiation of pluripotent stem cells into striatal projection neurons: a pure MSN fate may not be sufficient

Huntington’s disease (HD) is an autosomal dominant inherited disorder leading to the loss inter alia of DARPP-32 positive medium spiny projection neurons (“MSNs”) in the striatum. There is no known cure for HD but the relative specificity of cell loss early in the disease has made cell replacement b...

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Detalles Bibliográficos
Autores principales: Reddington, Amy E., Rosser, Anne E., Dunnett, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251433/
https://www.ncbi.nlm.nih.gov/pubmed/25520619
http://dx.doi.org/10.3389/fncel.2014.00398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251433/
https://www.ncbi.nlm.nih.gov/pubmed/25520619
http://dx.doi.org/10.3389/fncel.2014.00398

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