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Differentiation of pluripotent stem cells into striatal projection neurons: a pure MSN fate may not be sufficient
Huntington’s disease (HD) is an autosomal dominant inherited disorder leading to the loss inter alia of DARPP-32 positive medium spiny projection neurons (“MSNs”) in the striatum. There is no known cure for HD but the relative specificity of cell loss early in the disease has made cell replacement b...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251433/ https://www.ncbi.nlm.nih.gov/pubmed/25520619 http://dx.doi.org/10.3389/fncel.2014.00398 |