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HIV-2 interaction with cell coreceptors: amino acids within the V1/V2 region of viral envelope are determinant for CCR8, CCR5 and CXCR4 usage

BACKGROUND: Human immunodeficiency virus 1 and 2 (HIV-1 and HIV-2) use cellular receptors in distinct ways. Besides a more promiscuous usage of coreceptors by HIV-2 and a more frequent detection of CD4-independent HIV-2 isolates, we have previously identified two HIV-2 isolates (HIV-2(MIC97) and HIV...

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Detalles Bibliográficos
Autores principales: Santos-Costa, Quirina, Lopes, Maria Manuel, Calado, Marta, Azevedo-Pereira, José Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251929/
https://www.ncbi.nlm.nih.gov/pubmed/25421818
http://dx.doi.org/10.1186/s12977-014-0099-3