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Improving clinical efficacy of adeno associated vectors by rational capsid bioengineering
Adeno associated vectors (AAV) have shown considerable promise to treat various genetic disorders in both preclinical and clinical settings mainly because of its safety profile. However, efficient use of AAV to deliver genes in immune-competent sites like muscles and liver requires very high doses w...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251935/ https://www.ncbi.nlm.nih.gov/pubmed/25425174 http://dx.doi.org/10.1186/s12929-014-0103-1 |